Half life of Alprazolam in hepatic insufficient patients
Biomedica. 2001; 17 (2): 4-6
em Inglês
| IMEMR
| ID: emr-56480
ABSTRACT
Alprazolam is a triazolobenzodiazepine which is primarily metabolized by the liver. To see its half life in hepatic insufficient patients tab. Alprazolam in a dose of 0.25 mg, B.D. was given orally to 15 such patients and 5 normal subjects taken as control. Drug was given for a period of 21 days to both groups. Blood samples were drawn at day 7 and 21. There was no remarkable change in half life on day 7 and 21, among control group. Same results were seen among hepatic group on both days but half life increased to about double on day 7 and 21, when compared to control ones. Thus, it was concluded that in hepatic insufficient patients, half life increases significantly due to alteration in hepatic biotransformation mechanism
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Triazolam
/
Falência Hepática
/
Meia-Vida
/
Hepatopatias
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Biomedica
Ano de publicação:
2001
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