Pharmaco-chemical investigations of plantago ovata aerial parts
Bulletin of Faculty of Pharmacy-Cairo University. 2001; 39 (1): 345-52
em En
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| ID: emr-56555
Biblioteca responsável:
EMRO
The ethanolic extract of aerial parts of Plantago ovata was successively fractionated into ether, ethyl acetate and n-butanol- ethyl acetate [5:1] soluble fractions. The phenolic fraction of the ether extract afforded the coumarins; imperatorin, xanthotoxin, bergapten, umbeliferone, xanthtoxol and marmesin. The unsaponifiable fraction revealed high percentage of beta-sitosterol and stigmasterol, while the saponifiable part indicated high percentage of palmitolenic and palmitic acids. The ethyl acetate extract afforded a major compound identified as verbascoside and four flavonoids identified as luteolin-7-0-beta-glucopyranoside, luteolin-4-0-beta- glucopyranoside, quercetin 3-0-rhamnoside and the highly methoxylated calycopterin. Also, the n-butanol-ethyl acetate extract showed the same compound verbascoside as a major component. All isolated compounds were identified by chemical and spectral methods of analysis. The analgesic and anti-inflammatory activities of the ethanolic extract fractions [Et2O, EtOAc and n-BuOH-EtOAc] and the major constituent verbascoside were determined on rats
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Índice:
IMEMR
Assunto principal:
Farmacognosia
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Ratos
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Extratos Vegetais
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Físico-Química
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Cumarínicos
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Flavonas
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Cobaias
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Antagonistas dos Receptores Histamínicos H1
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Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Revista:
Bull. Fac. Pharm.-Cairo Univ.
Ano de publicação:
2001