Reaction of benzoyl acetonitrile with acetoacetanilides: synthesis of some pyrazole, pyrimidine, pyrazolo [3, 4-b] pyridine and pyrido [2, 3-d] pyrimidine derivatives

ABSTRACT

The reaction of benzoyl acetonitrile [1] with acetoacetanilide derivatives 2a-c gave the acyclic products 3a-c, respectively. The reaction of 3a with hydrazines, urea, thiourea, aromatic aldehydes and malononitrile gave pyrazole, pyrimidine, pyrazolo [3,4-d] pyridine and pyrido [2,3-d] pyrimidine and pyridine derivatives