Renal transplantation in systemic scierosis in a bahrain male-case report and review of the literature

ABSTRACT

A 42- year-old Bahraini male, known case of scleroderma, underwent renal transplant for persistent renal dys function demanding frequent haemodialysis. The procedure was carried out using live related donor following HLA and cross match. Unilateral nephrectomy was also done in view of long-term intractable hypertension. Histopathology of the diseased kidney confirmed the renovascular changes consistent with scleroderma. Nearly six months following successful transplantation, the patient showed moderate renal dysfunction with hypertension. The allograft biopsy revealed no signs of acute or chronic rejection, but vascular changes of hypertension were evident and also subintimal edema in a medium sized artery, raising the possibility of early changes of scleroderma. The pathology on the allograft biopsy is discussed based on the previous experience on similar cases though scant in the literature