Effect of a broad spectrum antiparasitic drug ivermectin in acute and chronic experimental giardiasis using different dose regimens
Journal of the Egyptian Society of Parasitology. 2001; 31 (2): 419-428
em Inglês
| IMEMR
| ID: emr-57199
ABSTRACT
In this study, the maximal excretion of Giardia lamblia cysts was three weeks post infection [pi]. The administration of ivermectin subcutaneously proved to be effective in treating hamsters infected for two and three weeks, respectively. It was found that the dose of 300 mug/kg bw was much more efficient than 200 mg/kg bw. The cure rate was 99.1% in the former and 98.7% in the later. In chronic giardiasis where infection was kept for six weeks, the cure rate was 99.5% two weeks after treatment with 300 g/kg bw of ivermectin. An assessment of cure was performed also by histopathological examination of upper 2/3 of small intestine of the hamsters. Localization and counting of the parasite were carried out immunohistochemically
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Infecções Protozoárias em Animais
/
Ivermectina
/
Giardíase
/
Mesocricetus
Limite:
Animais
Idioma:
Inglês
Revista:
J. Egypt. Soc. Parasitol.
Ano de publicação:
2001
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