Angiotensin II-induced renal vasodilation mediated by cytochrome P-450 arachidonic acid metabolites

ABSTRACT

Activation of AT2 angiotensin II receptor release cytochrome P-450 arachidonic acid metabolites [CYP-AA]. The presence of the AT2 receptor and its ability to mediate renal vasodilation through CYP-AA metabolites were evaluated. Vascular response to angiotensin II in the isolated perfused kidney of the rat was evaluated in the absence and presence of angiotensin II AT1 and AT2 receptor blockers. Blockade of the AT1 receptor unmasked a vasodilatory response that was inhibited by AT2 receptor blockade and AA metabolism. The findings indicate that blockade of the AT1 angiotensin II receptor, activation of AT2 receptors, releases CYP-AA metabolites that induce renal vasodilation