association of blood pressure level and the change in some hematological, hormonal and metabolic parameters in essential hypertensive subjects

ABSTRACT

This study aimed to investigate some possible hematological, hormonal and metabolic disorders that might occur in patients with essential hypertension [EH]. The study was conducted on 30 patients with untreated mild EH as well as an age matched control group of 30 male subjects with normotension. Patients with EH had higher WBCs count and neutrophil percentage, plasma ACTH, serum [s] prolactin, plasma aldosterone, s. cortisol and s. insulin levels, s. AST, s. ALT, s. gamma glutamyl transferase, s. alkaline phosphatase activities and s. total bilirubin, s. glucose s. creatinine, s. urea and s. uric acid leve1s than their controls. However, there was a significant decrease in RBCs count, platelet count, lymphocyte percentage and s. albumin level in those patients as compared with their control levels. Correlation data indicated that in normotensives, there was a positive significant correlation between DBP and age, while there were negative significant correlations between DBP and height and between DBP and RBCs