Assessment of Serum Tumor Necrosis Factor-alpha and alpha-fetoprotein in HCV-related chronic liver disease patients
Suez Canal University Medical Journal. 2001; 4 (2): 159-171
em Inglês
| IMEMR
| ID: emr-58398
ABSTRACT
This study included two groups of HCV-related chronic liver disease [CLD] patients, 30 patients with compensated CLD, 30 patients with decompensated CLD in addition to 20 apparently healthy individuals who served as controls. For all the subjects, the following tests were done; complete history, clinical examination hemoglobin concentration and platelet count, liver function tests [LFTs], TNF-alpha and AFP. TNF-alpha and AFP measurement was done employing state-of-the-art solid-phase two-site chemiluminescent enzyme immunometric assay automated analyzer [immulite]. The study showed that there was significant elevation of TNF-alpha level in HCV-related CLD group in comparison to control subjects. However, no significant differences were observed between compensated and decompensate CLD groups. There was also a significant elevation of serum AFP levels in HCV-related CLD groups in comparison to control subjects. However, no significant differences were observed between compensated and decompensate CLD groups. A significant inverse correlation was found between serum albumin and serum TNF-alpha in compensated CLD group, also a significant direct correlation was found between serum ALP and serum TNF-alpha in decompensate CLD group. However, no correlation was found between serum TNF-alpha and any other assayed parameters including AFP
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Contagem de Plaquetas
/
Tempo de Protrombina
/
Alfa-Fetoproteínas
/
Doença Crônica
/
Hepatite C Crônica
/
Fatores de Necrose Tumoral
/
Testes de Função Hepática
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Suez Canal Univ. Med. J.
Ano de publicação:
2001
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