Effects of low dose aspirin and antioxidant on Haemostatic equilibria in females oral contraceptives

ABSTRACT

Abnormalities in coagulation equilibria and prooxidant antioxidant status have been observed in consequence to cigarette smoking and oral contraceptive pill use. The study aims to evaluate parameters of hemostatic equilibria and endothelial damage in females with thrombotic tendencies arising from oral contraceptive [OC] pill use for more than three years besides the cumulative impact of cigarette smoke inhalation [CSI]. As well assessment of the influence of cessation of CSI for six months in conjunction with therapeutic regimen involving low dose aspirin and antioxidant supplementation. Selected cases were within age range 27-35 years and included active smokers [GII n = 20] and passive smokers [G11 n=20]. For six months they followed a regimen of daily supplementation of low dose [75 mg] aluminum aspirin tablets and antioxidants [antox tablets and dietary resources] besides cessation or avoidance of cigarette smoke inhalation as well as use of conventional contraception instead of OC. The results illustrated variations in the evaluated parameters of hemostatic equilibria including protein C, protein S and thrombin antithrombin complex as well as of total antioxidant - capacity and lipid peroxidation product malonedialdehyde versus serum cotinine levels. These variations were more bronounced in passive than active smokers when values were compared to those assessed before commencing the six month regimen. The aforementioned therapeutic regimen provided appropriate changes after six months for passive smokers and should be extended for another six months for active smokers who stopped smoking to fulfill the regimen requirements for rebalancing of hemostatic equilibria