action of inositol hexanicotinate as antilipaemic on normal and hypercholesterolaemic rabbits

ABSTRACT

The effect of Inositol hexanicotinate [IHN] on serum lipid fractions and body weight was examined in both normal and induced-hypercholesterolaemic rabbits. Generally, Inositol hexanicotinate [IHN] slightly reduced the serum levels of lipid constituents total triglycerides, phospholipids and total cholesterol. However, these fractions were significantly decreased in serum of the induced hypercholesterolaemic rabbits. The body weights as well as the alpha, Beta and non-mobilized-lipoproteins were also reduced in serum of the hypercholesterolaemic animals. The role of the examined drug as anticholesterolaemic and antilipaemic agent was discussed