effect of perfusion pressure during cardiopulmonary bypass on gastric mucosal pH

ABSTRACT

The objective of this prospective randomized study was to investigate the effect of high and low perfusion pressure during cardiopulmonary bypass [CPB] on the gastric mucosal pH [pHim]. The study was carried out on 30 patients scheduled for elective valve replacement surgery and allocated randomly into one of two groups group I [n=14] managed by perfusion pressure of 70-90 mmHg during CPB and group II [n= 16] managed by perfusion pressure < 60 mmHg during CPB. All patients were subjected to the same method of anesthesia, monitoring, anticoagulation and myocardial protection. ABG, PCO[2] [R-a], pHim were recorded before, during, at the end of and one hour after CPB. The results of this study revealed that in contrast to high perfusion pressure low perfusion pressure was associated with significant gastric mucosal acidosis during and after CPB. So we can concluded that the use of perfusion pressure >/= 70 mmHg can prevent or attenuate gastric mucosal acidosis during open cardiac surgery