Effect of vitamin C on responses of isolated hearts to B-adrenergic stimulation
Zagazig University Medical Journal. 2001; (Special Issue-Nov.): 550-64
em Inglês
| IMEMR
| ID: emr-58681
ABSTRACT
The aim of this study was to investigate the possible protective action of vitamin C, in different doses against the oxidative damage induced by excessive beta-adrenergic stimulation by isoproterenol on the isolated perfused rat heart in a Langendroff preparation. The finding revealed that vitamin C in all doses used [100 mg, 200 mg and 500 mg] reduces the positive Chronotropic response of beta- adrenergic stimulation. Also, it improves the myocardial flow rate in response to isoproterenol infusion.On the other hand, the inotropic responsiveness to isoproterenol is only abolished [reduced peak developed tension] with the large dose of vitamin C 500 mg. Therefor, the benefits of vitamin C against the deletarious effects of excessive beta- adrenergic stimulation of the heart have been demonstrated, although the disadvantageous actions of the large doses of vitamin C should be safeguarded
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Ácido Ascórbico
/
Ratos
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Substâncias Protetoras
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Coração
/
Antioxidantes
Limite:
Animais
Idioma:
Inglês
Revista:
Zagazig Univ. Med. J.
Ano de publicação:
2001
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