Age-related changes in mineralized milieu of long bones of female albino rats. A study in line with postmenopausal osteoporosis

ABSTRACT

A study in line with postmenopausal Osteoporosis To investigate and quantify changes in the Bone mineral content [BMC] and Bone mineral density [BMD] between Reproductive and Postreproductive Aged Female Albino Rats, using DEXA scanner. Setting: Deptt. of Anatomy, Basic Medical Sciences Institute [BMSI], Jinnah Postgraduate Medical Centre [JPMC], Karachi Methodology: 20 adult female albino rats were used in this study, divided into two groups Group-A comprising 10 rats of post-reproductive age [15-21 months old] and group-B 10 rats of reproductive age [68 months old]. On completion of experiment all the animals were sacrificed and their bones i.e femur, tibia and humerus were removed and preserved in formalin. Later on comparative analysis was made between the groups based on BMC and BMD mapped out through DEXA scanning. The quantitative measurement carried out by DEXA scanner revealed that bones of groupB were found to have relatively higher level of BMC and BMD compared to group-A. The level of BMC and BMD in long bones of female albino rats was found to get declined with advancing age