Tamoxifen: a potential remedy against postmenopausal osteoporosis

ABSTRACT

To study the effects of Tamoxifen on long bones, i.e. Femur, Tibia and Humerus of Postmenopausal Aged Female Albino Rats Setting: Basic Medical Sciences Institute [BMSI], Jinnah Postgraduate Medical Centre [JPMC], Karachi Specimens Ninety bones comprising humerus, femur and tibia [30 each] Methodology: Quantitative measurement of BMC [bone mineral content] and BMD [bone mineral density] carried out by DEXA [Dual Energy X ray Absorptiometry] Scanning Device; Qualitative changes mapped out through plain radiology. Bones, i.e. Femur, Tibia and Humerus of Tamoxifen treated group were found to have relatively increased levels of BMC and BMD. X-rays revealed that bones have greater cortical density in case of tamoxifen treated group. Tamoxifen helps preserving bone mass in bones of Aging Female Albino rats