Significance of thyroid function tests in growth retarded children

ABSTRACT

Growth retardation with or without mental retardation is a common problem in children. If remain untreated, patient may suffer permanent physical and mental disability. Aims and objectives of current study were to see the incidence of hypothyroidism in growth retarded children. Sixty nine children presenting with growth retardation were randomly selected, having advised thyroid function tests to investigate the cause of growth retardation. Their detailed history and clinical examination was done. Blood samples were drawn in plain containers, sera were separated and frozen. Batch analysis was done on BYK-Sangtec LIA-mat hormone analyzer. LIA-mat T3, fT4 and TSH kits were used based on the principle of luminescence immunoassay. Commercial LIA-mat controls were run with each batch. Clinical correlation of the results was done. Results revealed primary hypothyroidism in 4 cases and subclinical hypothyroidism in 4 cases. They were given thyroxine replacement therapy resulting in significant clinical improvement. Iodine deficiency may be a contributory factor. It was concluded that early detection of hypothyroidism and its prompt replacement car. prevent life threatening complications. Neonatal screening is recommended, as it is a routine in developed countries