Herpes simplex virus type-1 and apoptosis in pemphigus: a causal relationship
Egyptian Journal of Dermatology and Andrology. 2002; 22 (3): 11-24
em Inglês
| IMEMR
| ID: emr-59155
ABSTRACT
The objective of this study was to evaluate the possible role of herpes simplex virus type-I [HSV-I] infection and apoptosis in the etiopathogenesis of pemphigus vulgaris [PV]. The study included 29 patients with PV and 7 apparently healthy subjects as controls. The patients were grouped into three groups Group I [recent acute onset [6 cases]], group II [chronic exacerbated under steroid therapy [16 cases]] and group III [chronic controlled with steroid therapy [7 cases]]. Apoptosis was detected in peripheral blood monocytes [PBMC] using flow cytometry and that in the skin by TUNEL. HSV-I DNA was detected in PBMC and the skin using PCR. The antibody titer of serum IgG for HSV-I was detected using indirect immunofluorescence technique [IF]. The study concluded that apoptosis is increased in PV. Both HSV-I and apoptosis have to be considered in the immune-pathogenesis and can be used for immuno-modulation and suggestion of strategy of therapy or even to prevent exacerbation
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Reação em Cadeia da Polimerase
/
Apoptose
/
Herpes Simples
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Egypt. J. Dermatol. Androl.
Ano de publicação:
2002
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