Synthesis, molecular modeling and antitiumor activity of some substituted acridine derivatives

ABSTRACT

Nine series of new acridine derivatives of anticipated antineoplastic activity were synthesized. The first series consists of N,N'-1, 2-bis [9-[4-substituted sulfamoylphenyl] amino-acridine-4-carboxamide] ethylenediamine. The second comprises of N,N'-1,4-bis [9-[4- substituted sulfamoylphenyl] aminoacridine-4-carboxamide] phenylenediamine. The third and fourth are 1-[4-substituted sulfamoylphenyl] aminoacridine-4-carboxylic acid [4-substituted sulfamoylphenyl] amide. The fifth and sixth are 9-ox-1-[4-substituted amino sulfamoylphenyl]-9-10- dihydroacridine-4-carboxylic acid [4- substituted sulfamoylphenyl] amide. The seventh is 2-substituted phenyl-2,6-dihydropyrazolo [3,4,5-kl] acridine-5-carboxylic acid [4- substituted sulfamoylphenyl] amide. The eighth is 4-[5-[N'- phenylhydrazinocarbonyl-6H-pyrazolo [3,4,5-kl acridine-2-yl]-N- substituted benzene sulfonamide. The last one belongs to 2- substituted phenyl-2,6-dihydropyrazolo [3,4,5-kl] acridine-5-carboxyli acid [4-substituted sulfamoylphenyl] hydrazide