Protection against methanol intoxication in rat liver enzymes by vitamins C and E

ABSTRACT

Antioxidant [AO] effects of vitamins C and E on the alteration of some enzymes of glucose metabolism induced by repeated doses of methanol were studied in rat livers. The selected enzymes include hexokinase [HK], glucose phosphate isomerase [GPI] and pyruvate kinase [PK] as glycolytic enzymes as well as fructose 1,6-diphosphatase [F-1,6 DP] as gluconeogenic enzyme. The results showed that methanol caused a pronounced decay in the activities of the all measured enzymes. AO vitamins administration showed a high protective effects indicated by significant increase in the activities of these enzymes. This may be attributed to the inhibition of free radical production induced by toxic effect of methanol with subsequent minimum degree of tissue damage