Effect of intrathecal midazolam or midazolam-fentanyl with bupivacaine for cesarean section

ABSTRACT

Sixty healthy pregnant women at term scheduled for elective cesarean section under spinal anesthesia were randomly assigned to three equal groups, each of 20 women. The first group received 10 mg bupivacaine [B group], the second group received 2 mg midazolam added to 10 mg bupivacaine [BM group], while the third group received 2 mg midazolam, 10 mug fentanyl added to 10 mg bupivacaine [group BMF]. Midazolam significantly improved the quality of intraoperative anesthesia and analgesia, as none of the patients in BM group experienced pain which required analgesic supplement compared with eight patients in B group. Further more improved analgesia was achieved with the midazolam-fentanyl combination. The study concluded that adding a small dose of intrathecal midazolam to bupivacaine improved the quality of anesthesia reduction of the postoperative pain and reduction of analgesic consumption for cesarean section delivery. Combining midazolam with fentanyl much further improved analgesia without increasing the side effects