Biochemical and histological effects of verrucarin Y-toxin on adult male mice liver

ABSTRACT

The aim of the present work was to evaluate the effects of verrucarin J-toxin on serum biochemistry and on light and electron microscopic structures of the liver of adult male mice. Treated mice was injected intraperitonealy by toxin in a single dose of 0.9 mg/kg [group A] and 0.5 mg/kg body weight [group B]. The animals were sacrificed after 2, 4, 6 weeks [10 each] and compared to toxin free control [C] group. Results indicated that glucose level was significantly different in the treated groups [A, B], which were injected for 2 and 4 weeks than control [C] group. But there was no significant difference in 6 weeks. Plasma levels of triglycerides or cholesterol were significantly higher in both treated mice than control. Many histological changes occurred in the liver cells of both treated groups [A and B] after 2 and 4 weeks. The hepatocytes were engorged with glycogen. The nuclei and cell organelles are markedly affected. After 6 weeks from treatment many hepatocytes were, somewhat similar to the control