relation between histamine and serotonin plasma levels and renal diseases in children

ABSTRACT

Plasma histamine and serotonin concentrations were measured using fluorimetric assay in 40 children with renal diseases, minimal change nephrotic syndrome, focal segmental go-merulosclerosis and acute poststreptococcal glomerulo-nephritis to determine the relation between plasma level of histamine and serotonin and these various types of renal diseases in children. Plasma histamine level was significantly increased in group of children with acute poststreptococcal glomerulonephritis Plasma serotonin levels were significantly increased in all 3 groups of patients when compared with those of controls. Raised plasma hisiamine in acute poststreptococcal glomerulonephritis group may be evidence of the acute immu-nological inflammation and defective renal excretion due to mild renal impairment in these children. Raised plasma serotonin in all 3 groups of patients may be due to diminished uptake and release of serotonin from platelets in children with nephrotic syndrome and focal segmental glomerulosclerosis and due to defective renal excretion in children with acute post-streptococcal glomerulonephritis