correlation between the immunohistochemical expression of mutant P53 protein and HER-2/neu with clinical behaviour of infiltrating duct carcinoma of breast

ABSTRACT

A series of 40 females complaining of infiltrating duct carcinoma was included in this study. Clinicopathological background, histological grade and immunohistochemical staining for p53, HER-2/neu as well as estrogen and progesterone receptors were analyzed. The results showed that 14 cases were positive to p53, 12 were positive to HER-2/neu, 30 were positive to estrogen receptor and 22 were positive to progesterone receptors. The statistical analysis showed a positive correlation between p53 protein staining with tumor grade and an invasive relation to the hormonal status; whereas, HER-2/neu showed a significant correlation to the lymph node status. No correlation was detected between p53 protein, HER-2/neu protein expression and progression free survival. HER-2/neu protein-positive patients showed an improved response to anthracycline-containing regimen. A complete response was attained in 5% of the cases, partial response in 25%, stationary disease in 60% and 10% of the cases had progressive course