Biokinetics of inorganic iron in female volunteers

ABSTRACT

Iron biokinetics of absorption and disposition were investigated following a single oral dose of 150 mg ferrous sulfate to 10 healthy female volunteers. The blood and serum samples collected at different time intervals were analyzed by atomic absorption spectrophotometer. Total iron in blood showed about 25% lower values than those given in literature. In blood, iron showed mean +/- SD value of Tmax 2.37 +/- 0.17 hours, Cmax 422 +/- 26.9 mcg.m/L t1/2mcg 0.54 +/- 0.03 hour, kabs 1.29 +/- 0.08/h, AUC 6923 +/- 1624 h.mg/L, CI 0.36 +/- 0.00 mL/h/Kg, Vd 5.36 +/- 0.02 mL/Kg and t1/2B 9.54 +/- 2.07 hour. In serum, iron showed mean ' SD values of Tmax 6.73 +/- 0.00 hour, Cmax 10.8 +/- 0.57 mcg.m/L, t1/2mcg 8.05 +/- 1.32 hour, kabs 0.09 +/- 0.01/h, AUC 412 +/- 91.8 h.mg/L, CI 6.80 +/- 0.07 mL/h/Kg, Vd 82.5 +/- 0.55 mL/Kg and t1/2B 8.59 +/- 0.96 hour