Role of hyperprolactinemia in fertility

ABSTRACT

Role of Hyperprolactinemia in fertility was studied. A total of 100 hyperprolactinemic women [16 to 40 years of age] were studied at Salma and Kafeel Medical Center, Islamabad.Of these patients 18 were normoprolactinemic [control] and were taken as control.Fertile hyperprolactinemic were 25 [30.49%] and infertile were 57 [69.51%]. In this retrospective study the patients were interviewed to record the marital status, hormonal levels, type of infertility and duration of infertility. The results show that fertile hyperprolactinemic women had significantly [P<0.001] increased prolactin level, decreased LH and E2 [P<0.01] level during follicular phase compared with normoprolactinemic group. During ovulatory phase, fertile hyperprolactinemic women had significantly [P<0.001] increased prolactin level, decreased FSH and progesterone [P<0.05] level compared with normoprolactinemic group.In luteal phase these women had significantly increased prolactin level [P<0.001], decreased LH [P<0.01], FSH and E2 [P<0.05] levels compared with normoprolactinemic group. Hyperprolactinemic women with primary infertility [37; 64.91%] had significantly increased prolactin level [P<0.001], decreased LH and E2 [P<0.01] levels during follicular phase compared with control group. During ovulatory phase these women had significantly increased prolactin level [P<0.001], decreased LH, FSH levels and significantly [P<0.05] decreased progesterone level compared with normoprolactinemic group. In luteal phase these women had significantly increased prolactin level [P<0.001], decreased LH [P<0.02] and progesterone [P<0.01] levels compared with control group. Infertile [20;35.09%] hyperprolactinemic women with secondary infertility had significantly [P<0.001] increased prolactin level and significantly decreased LH level [P<0.01] during follicular phase compared with normoprolactinemic group. During ovulatory phase these women had significantly increased prolactin level [P<0.001], decreased LH [P<0.02] and E2 levels [P<0.05] compared with control group. During luteal phase these women had significantly increased prolactin level [P<0.001], decreased LH [P<0.02], FSH and progesterone [P<0.05] levels compared with normoprolactinemic group. It is concluded that hyperprolactinemia leads to infertility and its prevalence is higher in infertile women as compared to fertile women