Acute lymphoblastic leukemias; haematologic comparison between two treatment protocols

ABSTRACT

The present study conducted by the authors showed that in 1st group out of 21 cases, 3 left and remaining total 18 patients of ALL who received conventional treatment 16 [92%] showed complete remission and 2 died showed non-remission. In this group 10 [62%] showed complete remission after 2 months while 6 [38%] showed remission after 3 months. Similarly in 2nd group out of 21 cases, 4 left and in remaining 17 patients who received conventional therapy without L-asnase 16 [94%] showed complete remission and 1 [8%] died. The 16 patients who were in remission and received conventional treatment along with L-asnase enzyme showed complete remission in 14 [87%] cases after 2 months of treatment and 2 [13%] after 3 months of duration. The estimation of various parameters were continued till 6 months which showed maintenance of remission in 15[94%] patients in 1st group and all [100%] patients in 2nd group. This showed that the recommended chemotherapy without any L-asnase is less effective as induction of remission therapy while the addition of L-asnase enzyme in that treatment resulted in intensification of results which are maintained for longer time