Reflection of some hormones and bio-elements changes on bone mineralization in hemodialyzed chronic renal failure patients

ABSTRACT

The aim of the present study was to determine the relationship between bone mineralization and kidney dysfunction in patients on regular hemodialysis and whether there is any effect of hemodialysis on some essential trace elements that affect the bone strength. The study was carried out on 20 subjects suffering from chronic renal failure undergoing hemodialysis [HD-CRF] and 20 matched healthy subjects as a normal control group. A significant decrease in serum calcium, calcitonin and aldosterone levels was detected in HD-CRF group as compared with the corresponding levels in the normal control group. Meanwhile, there was a significant increase in serum total alkaline phosphatase activity and total protein level in HD-CRF group as compared with their respective values in the normal control group. Oxidative stress was assessed by estimating some trace elements [Se, Cu, Zn and iron] as well as NO in serum. The results showed a significant increase in serum NO and iron levels concomitant with a decrease in serum Se, Cu and Zn levels in HD-CRF patients as compared with the normal control ones. In conclusion, a physiological distress is often detectable in HD-CRF patients. This includes the disturbance in the hormonal and trace element status that strongly affects bone mineralization