Genotypes and allele frequencies of angiotensin converting enzyme [ACE] insertion/deletion polymorphism among Omanis

ABSTRACT

To describe the angiotensin converting enzyme [ACE] genotype frequencies among Omani Arabs. A polymerase chain reaction [PCR] test, based on separation of different size DNA fragments, was developed to test the presence or absence [polymorphism] of a small DNA deletion in the ACE gene. The subjects were 124 Omani Arab students of Sultan Qaboos University, Muscat. The frequency of the I allele was 0.29, while that of the D allele was 0.71. The gene frequency distribution did not deviate from Hardy-Weinberg equilibrium. The frequency of D allele among Omanis is similar to that among other Arabs and Africans, but differs significantly from that among the Japanese and Chinese