Expression of P27 in prostatic adenocarcinoma

ABSTRACT

The objective of this study was to evaluate p27 expression in prostatic adenocarcinoma and to assess its association with some morphologic and clinical features. A sample of 69 specimens of prostatic adenocarcinoma were evaluated for p27 expression by quantifying nuclear immunohistochemical staining, p27 expression was tested for association with patient age, family history of prostate cancer and preoperative serum prostate-specific antigen level, p27 expression was analyzed as a continuous variable and the tumors were classified as low expressors [<50% of cells p27 positive] or high expressors [>50% of cells p27 positive] for comparison. Patients with adenocarcinoma that exhibited low p27 expression had higher mean Gleason scores than did high expressors [7 vs. 6.2, respectively]. The evaluation of p27 expression might provide additional prognostic information