Effect of p-CPA pretreatment on EEG power spectra in experimental open brain injury in rats
IBJ-Iranian Biomedical Journal. 2003; 7 (3): 119-26
em Inglês
| IMEMR
| ID: emr-62251
ABSTRACT
Continuous four hours EEG [electroencephalogram] recordings and its power spectrum analysis using fast fourier transform [FFT] in urethane anesthetized male Charles Foster rats were performed in two groups open brain injury and p-CPA [para-Chlorophenylalanine] pretreated before brain injury, respectively, and compared with the EEG power spectrum of control rats. The EEG power spectrum analysis showed that there was a faster recovery in p-CPA pretreated group than the injury group of rats. The results showed that the p-CPA [a 5-HT inhibitor] prevents pathological changes following brain injury. Simultaneously, the inference can also be drawn that EEG power spectrum analysis is a useful technique for monitoring the brain injury and its recovery following pharmacological treatments
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Ratos
/
Análise Espectral
/
Lesões Encefálicas
/
Fenclonina
/
Eletroencefalografia
Limite:
Animais
Idioma:
Inglês
Revista:
Iran. Biomed. J.
Ano de publicação:
2003
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