gastroprotctive effect of transdermal nitroglycerin and its underlying mechanisms in ethanol induced gastric ulcer in rat

ABSTRACT

Nitric oxide donors proved to have gastroprotective effect experimentally but the clinical applicability of this effect is limited by pharmaceutical nature of these drugs. Transdermal nitroglycerine adhesive patches [TNAP] is a safe clinically used preparation provide a continuous administration of NO with constant rate the aim of this study is to evaluate the effect of [TNAP] on ethanol induced gastric ulcer in rats and the possible underlying mechanisms. TNAP caused significant improvement in ethanol, 90%, induce gastric ulcers in rats. This improvement is represented by significant reduction of Ulcer index [56%], volume of gastric secretion [40%], titrable acidity [67%], peptic activity [62%], mucin concentration in gastric secretion [36%] and vascular Permeability expressed as [g Evans blue/g. tissue [47.6c1] compared with rats received 1 ml/rat ethanol P.O. TNAP release 20-25 micro g/cm3/h for 2 hours [400-1000 micro g/rat as surface area of TTS-5 used in this work is 10 cm[3]] proved to have gastroprotective effect against ethanol 90% [Topical acute injury]. This gastroprotective may be mediated by reduction of acid secretion and peptic activity, reversal of ethanol induced inhibition of mucin binding protein and vascular damage