Effect of chloroquine on liver weight of developing albino rats

ABSTRACT

To see the effect of chloroquine on liver weight of developing albino rats. Twenty four pregnant female albino rats were used and divided in 4 groups. They were kept in Animal House of Post Graduate Medical Institute, Lahore. Total gestational period in rats ranges from 20-22 days, which in this study was divided into three trimesters, each of seven days. Using oral dose of chloroquine 700mg/kg body weight in first second and third weeks of pregnancy. Chloroquine caused decrease in liver weight in offsprings specially in those which were exposed to drug during second and third week of pregnancy. The use of chloroquine should be avoided during pregnancy