Lipoxins and lipoxin analogues as potential novel therapeutics in acute renal failure and glomerulonephritis

ABSTRACT

Lipoxins [LX] are lipoxygenase-derived lipid mediators with both anti-inflammatory and pro-resolution properties in model systems in vitro and in vivo. The bioactivity profile of LX in vitro suggests that they have therapeutic potential in acute renal failure and glomerulonephritis; predictions that have been borne out to date in experimental models of renal disease