Diurnal pattern of plasma endothelin-1: effect on endothelium-dependent vasodilatation in patients with stable angina pectoris
Mansoura Medical Journal. 2003; 34 (1-2): 207-230
em Inglês
| IMEMR
| ID: emr-63418
ABSTRACT
This study included two groups of patients Group I included 20 patients with stable angina pectoris [SA] [18 men and 2 women, aged 50.51 +/- 8.29 years] and group II included 20 healthy subjects [17 males and 3 females, aged 48.11 +/- 6.31 years] taken as a control group. Flow-mediated vasodilatation [FMD] of the brachial artery [a surrogate for endothelium-dependent vasodilatation] was determined by ultrasound at 8 a.m. and 8 p.m. Also, carotid artery intima-media thickness [IMT] was determined by ultrasound. The plasma levels of C- reactive protein [CRP] and ET-1 were determined at 8 a.m. and 8 p.m. The study included that the normal subjects had diurnal variation in endothelium-dependent vasodilatation that may counteract other, potentially adverse, diurnal variations in the hemodynamic and other parameters. In contrast, patients with SA showed a loss of this protective mechanism. No diurnal variation in plasma CRP was found to explain this finding. Diurnal variation in plasma ET-1 levels is likely one of the mechanisms involved in the pathogenesis of this phenomenon
Buscar no Google
Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Vasodilatadores
/
Proteína C-Reativa
/
Biomarcadores
/
Ritmo Circadiano
/
Endotelina-1
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Mansoura Med. J.
Ano de publicação:
2003
Similares
MEDLINE
...
LILACS
LIS