Polycystic ovary syndrome [PCOS] - the highly significant associated hormonal and biochemical parameters in normal and polycystic-appearing ovary groups

ABSTRACT

To evaluate what hormonal and/or biochemical parameters are highly associated with polycystic ovary syndrome [PCOS] in ultrasonically normal and polysticappearing ovary groups. A prospective randomized comparative study El Galaa Maternity Teaching Hospital Patients[s] Thirty two women fulfilling the entry diagnostic criteria for PCOS were randomly subdivided into two groups-group I [n=16] with ultrasonically normal-appearing ovaries and group II [n=16] with characteristic polycystic ovarian morphology. The two groups were matched for age and body mass index [BMI]. All patients had elevated serum testosterone [T] level between 80 and 150 ng/dL i.e. androgen excess. Insulin infusion for the purpose of performing insulin tolerance testing to evaluate insulin resistance or sensitivity. We measured serum androgens [T, DHEAS and androstenedione], gonadotorophins [FSH and LH], binding proteins [sex hormone-bending globulin SHBG and insulin-like growth factor binding protein-1, IGFBP-1], insulin-like growth factor-1 [IGF-1] and insulin resistance by insulin tolerance testing [ITT]. Serum androgens and binding proteins were not significant different in both groups. Insulin tolerance testing demonstreated a slower glucose disappearance in the polycystic-appearing ovary group. K-itt] glucose was 4.58% +/- 1.4% / min and 2.07% +/- 1.07% min in the normal and polucystic-appearing ovaries group respectively. Women with PCOS and polcystic ovarian morphology do not demonstrate any definitive serum hormonal differences compared with women with PCOS and normal-appearing ovaries. The presence of polycystic-appearing ovaries correlates significantly with the presence of insulin resistance, a findings that highlights the long-term health consequences of the syndrome