Corrective action of carnosine on liver enzymes in ethanol intoxication

ABSTRACT

The changes in activities of certain enzymes in the liver of ethanol ingested rats and the corrective action of carnosine treatment was studied in the present work. These enzymes included, alcohol dehydrogenase [adh] and some enzymes of energy metabolism including, hexokinase hk. Phosphofructokinase [pfk], malate dehydrogenase [mdh] and creatine phosphokinase [cpk]. Ethanol ingestion showed a marked reduction in the activities of energy metabolism enzymes, indicating the toxic effect of ethanol by inducing oxidative stress on liver tissues, administration of carnosine ameliorated the toxic action of ethanol by improving the activities of the four energy metabolism enzymes