Effect of laparoscopy on hepatic function

ABSTRACT

To asses the effects of laparoscopic surgery on liver function, plasma concentration of alcoholic dehydrogenase [AD] and glutathione s- transferase [GST] was measured, which are highly concentrated into centrilobular acinus of liver and are sensitive enzymes of hepatic hypoperfusion and hepatocellular damage. Fifty patients underwent laparoscopic cholecystectomy [group A, n=25] or laparoscopic hysterectomy [group B, n=25] were studied. Perioperative AD, GST, aspartate aminotransferase [AST] and alanine aminotransferase [ALT] in both groups was compared. Although the duration of pneumoperitoneum was longer in laparoscopic hysterectomy there was significant postoperative increase in AD and GST in the laparoscopic cholecystectomy group at the end of procedure and 1 hour after surgery compared with the laparoscopic hysterectomy group. AST and ALT concentration were significantly higher in first postoperative day in the laparoscopic cholecystectomy group than in the laparoscopic hysterectomy group. These results indicated that patient position and surgical manipulation of the liver affect significantly hepatic perfusion