Hemostatic disturbances in hepatitis B virus infection patients

ABSTRACT

This study was conducted on 20 patients [14 males and 6 females] with chronic hepatitis B virus infection and their ages ranged between 30-50 years and 10 control males. The aim of this study was to assess the hemostatic abnormalities in chronic hepatitis virus infection. All patients were subjected to full history, clinical examination, abdominal ultrasound and laboratory investigations [CBC, LFTS, HBsAg, PT, APTT and coagulation factors I, II, V, VII, VIII, IX, XI and XII]. The results of this study revealed that higher level of factors VII, VIII and factor XI and decreased level of factors IX and XII reflecting the lesser degree of prolongation in PT and APTT. It was concluded that abnormal hemostasis is a common complication of lever diseases and determination of its underlying pathogenesis is essential foe rational management. Vitamin K coagulation factor IX was diminished