Micronuclei induction by some anthelmintic drugs in male mice

ABSTRACT

This work aimed to evaluate the ability of anthelmintic drugs [albendazole, oxfendazole, levamisole and ivermectin] to induce genotoxicity in mice. Micronucleus test was performed in bone marrow cells of male mice treated with the maximum tolerated dose of each drug tested at 24, 48, 72 hours after treatment. The results indicated that all tested drugs, except levamisole, were induced statistically significant increase in the number of micronucleated polychromatic erythrocytes [MNPCEs] at 72 hours, after treatment over than the negative control. Also, results showed that there are statistically significant differences between both of albendazole, ivermectin, levamisole and the positive control. In contrast, there were no statistically significant differences between oxfendazole and the positive control. This indicated that oxfendazole is the more sensitive drug to induce MNPCEs in mice bone marrow cells. It was concluded that the over dose use of that anthelmintic drugs may caused genotoxic effect for human