role of TC-99M tetrofosmin in the differentiation between bening and sarcomatous osseous and soft tissue lesions

In this study, 24 patients [16 males and 8 females with a mean age of 26.92 +/- 15.3 years] with uncertain diagnoses of benign and sarcomatous osseous and soft tissue lesions based on clinical and conventional radiological methods and MRI were evaluated. All patients were subjected to two imaging studies [using ADAC-Forte dual- head gamma camera attached to Sun Solaris computer] at 10 and 30 minutes after i.v. injection of Tc-99m tetrofosmin [13 MBq/kg body weight]. Processing to derive target to nontarget uptake ratios was done using pexils-matched region of interest [ROI] analysis for the 10 and 30 minutes images. The calculation of diagnostic validity parameters was based on a histopathological confirmation [open or core biopsy] which revealed 13 benign and 11 sarcomatous cases