Gestational trophoblastic diseases [GTD]: Curable or fatal diseases? A single institution experience

ABSTRACT

The aim of this study was to define the treatment results and causes of failure including treatment toxicity in 48 patients with gestational trophoblastic diseases [GTD]. The clinical records of the patients were reviewed with regards to presentation, investigation, management and outcome. Thirty-nine patients received chemotherapy as they maintained high serum BHCG after suction and termination of molar pregnancy and other nine patients showed a progressive decline within one week and kept under follow up. Due to the relatively high toxicity of 4-day methotrexate outpatient schedule, it was recommended to shift to 1-day IV basis schedule. In case of extensive pulmonary metastasis, initial co-management with pulmonologist and ICU will be very beneficial to prevent ERD starting very carefully