Assessment of the stability of different brands of ampicillin oral suspensions

ABSTRACT

Assessment of the stability of ampicillin trihydrate oral suspensions 250 mg/5 ml of three different commercial brands [Ultracillin[R]], [lpcacillin[R]], [Ampicillin mixture[R]] and ampicillin trihydrate as a reference sample has been tested by using lodometric assay. Ampicillin [trihydrate] oral suspension was reconstituted with different vehicles and stored at different temperatures, [Fridge 5°C] and [Room 25°C] for one week. The effect of vehicles, temperatures, electrolytes, antioxidant and buffers on stability of ampicillin [trihydrate] oral suspensions was studied. lodometric assay was applied to determine the percentage of the degradations of ampicillin trihydrate oral suspension. The rate of ampicillin trihydrate degradation from sustained release suspension after aging has been studied using first order kinetic reaction. We determined in the laboratory the effect of the type of water used in preparing the antibiotic suspension on stability. The shelf lives were also studied