experimental study of albino rats fed on nigella sativa and aspirin for four weeks duration: determination of coagulation profile

ABSTRACT

Ninety albino rats were selected and were divided into six groups on the basis of different diets given. Control group [I] was fed on synthetic diet and experimental groups [IIA, IIB, IIC, IID and IIE] were fed on 1 mg aspirin, 15mg, 30 mg, 45 mg Nigella Sativa per kg body weight respectively while HE was given 30 mg NS and 1 mg aspirin/kg body wt. Blood samples were collected by heart puncture and Coagulation parameters were done. BT was prolonged in groups taking aspirin only. APTT was reduced significantly in groups taking different concentration of NS when compared with control. Percentage of clot retraction was weak significantly in groups taking aspirin only when comparing with other groups