Compensatory renal hypertrophy following unilateral nephrectomy in albino rats

ABSTRACT

This study was carried out on 72 albino rats [36 experimental and 36 control] following UNX and so we know the rate and extent of compensatory renal hypertrophy [CRH] of the remaining kidney. The mean absolute change in mass due to hypertrophy in the experimental kidney KW [compensatory] following unilateral nephrectomy after 10, 20, 30, 40, 50 and 60 days was 0.384 +/- 0.003, 0.674 +/- 0.005, 0.768 +/- 0.004, 0.926 +/- 0.006, 0.940 +/- 0.005 and 0.932 +/- 0.007 gm respectively. The mean relative change in mass due to hypertrophy in the experimental kidney,%KW[compensatory following unilateral nephrectomy after 10, 20, 30, 40, 50 and 60 days was 46.36 +/- 0.84, 77.66 +/- 1.16, 91.43 +/- 0.96, 105.71 +/- 0.77, 110.15 +/- 0.77 and 112.08 +/- 1.89 respectively. It was concluded that there was rapid compensatory increase in the renal mass of the experimental kidney within first 10 days, the mean relative compensatory increase in the renal mass of the experimental kidney was 46.36 +/- 0.84% than the control. From the 11th day to the 40th day there was a steady compensatory increase at a slower rate [59.35% in 30 days] until the mean relative compensatory increase in the renal mass of the experimental kidney had reached 105.71 +/- 0.77% of the control value