Toxicological potential to mice of 14C-arbaryl bound residues in faba and soybeans

ABSTRACT

Sound faba and soybeans were treated with 14C-carbaryl at a dose of 16 mg insecticide/kg grains and stored under local conditions. After 30 weeks of storage the amount of surface residues was 29%, 27% and the internal residues amounted to 56%, 60% in faba and soybeans, respectively. 14C-Bound residues [non-extractable] after 30 weeks of storage was 5% and 6% in faba and soybeans, respectively. Feeding mice for 3 months with a diet containing 14C-carbaryl bound residues in faba and soybeans revealed that these residues have a slight effect and no significant symptoms of toxicity towards mice were observed. A slight inhibition in both plasma and erythrocyte-cholinesterase activity was clear during the first 2 weeks of the experiment with both seeds. Haematological studies showed only a significant decrease in the white blood cell counts as compared with the control mice. The level of blood serum esterases showed a slight increase in liver and kidney functions as compared with controls. Significant differences were clear in kidney function where blood urea nitrogen was increased by [45%, 58%], and creatinine level was elevated by [20%,28%] after 3 months of feeding with faba and soybeans, respectively