Assessment of human AT1 binding affinity of some novel 2-alkylthio 1- [4- [N-alpha-ethoxycarbonyl-benzyl] aminobenzyl] -5 hydroxymethylimidazoles
DARU-Journal of Faculty of Pharmacy Tehran University of Medical Sciences. 2004; 12 (1): 31-5
em Inglês
| IMEMR
| ID: emr-65634
ABSTRACT
Antagonists of various components of the renin-angiotensin system have been the subject of many studies for the control of blood pressure. Compounds with a phenoxyphenylacetic acid moiety that mimic the structure of losartan which is a powerful competitive antagonist of angiotensin receptor, have shown to be effective. In this study, the affinity of some 2-alkylthio-1-[4-[N- alpha -ethoxycarbonylbenzyl]aminobenzyl]-5-hydroxymethyl imidazoles for the human AT1 receptor was assessed in a radioligand binding assay. It was found that an alkyl chain of appropriate length would be most suitable if situated on the imidazole ring. Furthermore, variations of the lower phenyl rings demonstrated that introduction of a methyl group in this position will account for the most desired effect
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Ensaio Radioligante
/
Angiotensina II
/
Losartan
/
Imidazóis
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Humanos
Idioma:
Inglês
Revista:
J. Fac. Pharm. Tehran Univ. Med. Sci.
Ano de publicação:
2004
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