Novel 5,6,7,8-Tetrahydronaphth-2-yl heterocycles of possible biological activity
Egyptian Pharmaceutical Journal [National Research Center]. 2004; 3: 49-65
em Inglês
| IMEMR
| ID: emr-65794
ABSTRACT
2-cyclocondensation 2 underwent with different alpha-cyanocinnamonitriles to give the corresponding poly substituted pyran derivatives 3[a-d] which upon treatment with carbon disulphide gave the pyranopyrimidindithione derivatives 4[a-c]. Also, treatment of 2 with different aldehydes afforded the corresponding cinnamonitrile derivatives 5[a,b] which upon reaction with 3-methyl-1- phenylpyrazol-5-one gave the corresponding pyranopyrazole derivatives 6[a,b]. Moreover imidazo [2,3-b] thiazoles 8[a,c]; 1,2,3- thia- or 1,2,3- selena-diazoles 10[a,b]; thiazolidinones 16[a,b] and benzoxazin-4-one derivatives 18[a,b] derivatives were synthesized starting with 2-acetyltetralin. Compounds 3[c],11[b],12 were tested as antibilharzial agents and compounds 6[a],8[a] as antileukemia agents in experimental animals. Some of these compounds showed moderate activity
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Esquistossomicidas
/
Bioensaio
/
Espectroscopia de Ressonância Magnética
/
Compostos Heterocíclicos
/
Antibacterianos
/
Antineoplásicos
Idioma:
Inglês
Revista:
Egypt. Pharm. J. [NRC]
Ano de publicação:
2004
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