Homocysteine: an independent risk factor in atherogenic process

ABSTRACT

Following oral administration of methionine in high dose, 200 mg/kg during 21 days to rats, its degradation product, homocysteine [HC] which is markedly elevated in serum exerts an angiotoxic action directed to the aortas. This is shown in degradation and desquamation of endothelial cells, also formation of foam cells in the media with dissolution of mediocytes and formation of tissue gaps. These changes are not seen in animals administered with methionine and treated with vitamins B[6], B[9] and B[12]. Because these vitamins serve as cofactors for enzymes which are required for the regulation of methionine level, so vitamins therapy in rats has reduced homocysteine in plasma