new approach to control of symptoms in vasomotor rhinitis of pregnancy

ABSTRACT

Vasomotor rhinitis of pregnancy has long been identified as a problem encountered by many pregnant females, this accompanies the drastic physiologic changes that occur during pregnancy. We aimed to determine the validity and efficacy of use of a well known safe drug which can be used in pregnancy, namely micronised purified diosminhesperidin combination [Daflon[R] Servier] in the improvement of symptoms of females suffering from vasomotor rhinitis of pregnancy [VMRP] and comparing it to the use of a local nasal steroid Fluticasone propionate [Flixonase[R], GSK], and a combination of both drugs. Forty-eight pregnant females suffering from symptoms and signs of VMRP contributed in the study. Subjective grading was done using the 7 most related items from the modified sinonasal outcome test [SNOT] scale scoring system, and objective grading using the rhinoscan acoustic rhinometer [by Rhinometrics[R]]. Results showed that the Diosmin-hesperidin combination only group showed similar response to combination of Diosmin-hesperidin combination and Fluticasone propionate, and both groups gave better response than the Fluticasone propionate only group. In conclusion, Diosmin-hesperidin combination is a safe and effective treatment line in control of symptoms of VMRP, either alone or in combination with Fluticasone propionate