association between vesicoureteral reflux and HLA class I antigen

ABSTRACT

vesicoureteral reflux is a retrograde propulsion of urine into the upper urinary tract during bladder contraction. Five grades were standardized based on degree of dilatation affecting the ureter and renal collecting system. The main etiological factor is the genetic predisposition. To find if there is a correlation between HLA class I antigen and VUR. A study was conducted on 25 VUR patients admitted to the Medical City Hospital and 50 normal individuals selected from healthy kidney donors attending kidney transplantation unit in the period between August 2002 and February 2003. HLA typing to HLA class I antigen using standard microlymphocytotoxicity technique was done for each individual. HLA class I antigens were detected in each group, which showed higher frequencies for HLA-A23, A25 and B16 among VUR patients, yet no statistical significance was observed