Captopril failed to attenuate the vascular response in type 2 diabetes with microalbuminuria

ABSTRACT

This study is designed to study the effect if captopril on forearm blood flow aiming to understanding the mechanism of vascular response in type 2 diabetics with microalbuminuria. Department of pharmacology, College of Medicine, Al-Mustansiriyah University, Baghdad- Iraq Design; Arandomized Controlled-Clinical Trial. -24Hour Uriary Albumin Excretion -Echocardiogarphic Study -Doppler Ultrasonographic Study of Brachial Artery. The Initil echocardiographic data of diabetics with regarding the left ventricular dimensions. Single dose of nitroglycerin alttreed theleft ventricular dimension of controls but not the diabetics. Captopril of 12.5 mg/day for 7 days resulted in a significant effect on the aortic root dimension in controls but not in diabetics. Doppler study revealed that reactive hyperemia produced a significant improvement in brachial blood flow in controls rather than in diabetics in term of mean velocity. Nitroglycerin improved the blood flow in diabetics by 11.7% increment of mean velocity Vs 3.4% in controls, while captopril failed to show this effect [7.0% Vs 1.7% increment in controls and diabetics respectively]. The vascular response in type 2 diabetes mellitus with microalbuminuria was influenced by dysfunction rather than the structure of blood vessels by the evidence of effect of nitroglycerin and not captopril